Theophylline, Chemical Formula and Skeletal Structure Stock Vector Illustration of geometric
Dose: 0.2 mg/kg/h IV; Start: load 5 mg/kg/dose IV x1 if no theophylline w/in 24h; Info: not recommended per NIH guidelines; adjust dose based on serum levels; reduced clearance risk factors include hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, and hypothyroidism.
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Generic Name Theophylline DrugBank Accession Number DB00277 Background. A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities.
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Theophylline is a medication used to treat asthma and chronic obstructive pulmonary disease as a second-line drug. It is a bronchodilator. This activity reviews the indications, action, and contraindications for theophylline as a potential agent in treating asthma and chronic obstructive pulmonary disease. This activity will highlight the mechanism of action, adverse event profile.
Theophylline uses, safety, toxicity, side effects & dosage
Theophylline, a drug that has been used for several decades, has several different actions at a cellular level, including inhibition of phosphodiesterase isoenzymes, antagonism of adenosine, enhancement of catecholamine secretion, and modulation of calcium fluxes. Recently, theophylline was found to have several immunomodulatory and anti-inflammatory properties, and thus interest in its use in.
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EP0322137B1 1992-05-27 Spray dried ibuprofen. WO1983000284A1 1983-02-03 Sustained release theophylline. IE64084B1 1995-07-12 Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat. IE862493L 1987-04-11 Controlled release pharmaceutical preparations.
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Typical dosing for Theophylline. Children who weigh less than 45 kg (99 lbs) typically start with 12 to 14 mg/kg per day, but no more than 300 mg in a day. Their dose can be as high as 20 mg/kg per day, but no more than 600 mg in a day. Adults and children who weigh over 45 kg typically start with 300 to 400 mg per day.
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The invention discloses a high-yield synthesis method for theophylline. The high-yield synthesis method for theophylline comprises the following steps: adding dimethyl sulphate, 6-aminouracil, a sodium hydroxide solution and water in a reaction container, stirring in an ice-salt bath, filtering, washing and drying to obtain 6-amino-1,3-dimethyluracil; adding 6-amino-1,3-dimethyluracil, acetic.
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Side Effects. Nausea / vomiting, stomach / abdominal pain, headache, trouble sleeping, diarrhea, irritability, restlessness, nervousness, shaking, or increased urination may occur. If any of these.
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Theophylline may cause serious side effects. Call your doctor at once if you have: severe or continued vomiting; ongoing headache, trouble sleeping; rapid heartbeats; a seizure; new signs of illness (especially fever); low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination.
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The theophylline is coated onto a sugar/starch pellet by means of an adhesive such as cellulose acetate phthalate which will not dissolve in stomach juices. [0009] U.S. Patent No. 4,261,970 describes a sustained release theophylline granule containing a metal salt of a fatty acid and ethyl cellulose.
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Theophylline comes as an extended-release (long-acting) tablet, extended-release capsule, and a solution (liquid) to take by mouth. It usually is taken every 6, 8, 12, or 24 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
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This includes your doctors, nurses, pharmacists, and dentists. This drug may affect certain lab tests. Tell all of your health care providers and lab workers that you take this drug. Wear disease medical alert ID (identification). Have blood work checked as you have been told by the doctor. Talk with the doctor.
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Extended release formulations: Initial dose: 300 to 400 mg once daily; maintenance: 400 to 600 mg once daily (maximum daily dose: 600 mg/ day) Dosage adjustment based on serum theophylline concentrations: Infants, Children, and Adolescents: Note: Recheck serum theophylline concentrations after 3 days when using oral dosing, or after 12 hours.
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Some of the more common side effects that can occur with use of theophylline include: headache. trouble sleeping. If these effects are mild, they may go away within a few days or a couple of weeks.
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Theophylline extended-release tablets in Japan. Theophylline, also known as 1,3-dimethylxanthine, is a drug that inhibits phosphodiesterase and blocks adenosine receptors. It is used to treat chronic obstructive pulmonary disease (COPD) and asthma. Its pharmacology is similar to other methylxanthine drugs (e.g., theobromine and caffeine). Trace amounts of theophylline are naturally present in.
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Theophylline | C7H8N4O2 | CID 2153 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety.