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Tablet and oral solution: for pediatric patients 4 through 11 years of age the dosage is one 4 mg Ondane tablet or 5ml of Ondane solution should be administered 3 times a day for 1 to 2 days after completion of chemotherapy. Injection: the dosage in pediatric patients 4 to 18 years of age should three .15-mg/kg doses.
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Prophylaxis. Total body radiation therapy: 8 mg PO 1-2 hours before radiation therapy; administered each day. Single high-dose fraction therapy to abdomen: 8 mg PO 1-2 hr before radiation therapy; administer subsequent doses every 8 hr after first dose 1-2 days after completion of therapy. Daily fractions to abdomen: Administer 8 mg PO 1-2 hr.
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Ondane mengandung ondansentron, dimana merupakan obat antiemetik yang digunakan untuk meredakan mual dan muntah akibat kemoterapi serta pencegahan mual dan muntah paska operasi. Ondansetron bekerja sebagai antagonis reseptor 5-HT3 yang memblok serotonin pada Chemoreceptor Trigger Zone (CTZ). Pemblokan ini menyebabkan efek antiemetik (anti mual.
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jaundice (yellowing of the skin or eyes); blurred vision or temporary vision loss (lasting from only a few minutes to several hours); high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting. Common ondansetron side effects may.
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Pharmacology : Ondansetron is a potent and selective 5-HT3 receptor antagonist. Administration of chemotherapy drugs and radiotherapy can cause the release of 5-HT3 into the intestine which will stimulate the gag reflex by activating vagal afferent fibers via 5-HT3 receptors. Ondansetron inhibits the initiation of this reflex.
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A person taking Ondan Syrup 30 ml often experience side effects that include a feeling of warmth, constipation, headache, diarrhoea, headache, drowsiness, feeling of tiredness. Although, not every person faces the side effects of Ondan Syrup 30 ml, and even some of the unpleasant effects of Ondan Syrup 30 ml do not require medical attention.
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Dosis. Dewasa : Untuk pencegahan mual dan muntah pasca operasi : 8 mg 1 jam sebelum anestesi, selanjutnya 8 mg tiap 8 jam sampai dengan 16 jam. Untuk mual dan muntah karena radioterapi : 8 mg per oral tiap 8 jam, 1-2 jam sebelum radioterapi. Anak > 4 tahun : 5 mg/m2 IV selama 15 menit, diberikat setiap 12 jam selama 5 hari.
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Dosis. PENGGUNAAN OBAT INI HARUS SESUAI DENGAN PETUNJUK DOKTER. Pencegahan mual muntah paska operasi Dewasa dan anak >17 tahun: Awal 8 mg per oral 1-2 jam sebelum anestesi, dilanjutkan dengan 8 mg setelah 8-12 jam. Anak 4-11 tahun: 4 mg 30 menit sebelum kemoterapi. Ulangi dosis setelah 4 dan 8 jam dari dosis awal Mual muntah paska operasi: 16.
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Ondansetron may cause serious side effects. Call your doctor at once if you have: headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; blurred vision or temporary vision loss (lasting from only a few minutes to several hours); severe constipation, stomach pain, or bloating; a light-headed feeling, like you might.
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Pharmacodynamics. Ondansetron is a highly specific and selective serotonin 5-HT 3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors Label, 3,4.The serotonin 5-HT 3 receptors are located on the nerve terminals of the vagus in the periphery, and centrally in the chemoreceptor trigger zone of the area postrema Label, 3,4.
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The typical dose of Ondane is 8 mg of Ondane 30 minutes before starting radiotherapy or chemotherapy, followed by 8 mg dose 8 hours after the first dose. The usual dose for children is for 12-17 years of children, 8 mg is given 30 minutes before the start of the therapy, followed by 8 mg dose 4 and 8 hours after the first dose, followed by 8 mg thrice a day after completion of therapy.
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Infectious Diseases Society of America (IDSA) Recommendations: 30 mg/kg orally once a day. Maximum dose: 1 gram/day. Duration of therapy: 10 days. Comment: This drug should be avoided in patients with immediate hypersensitivity to penicillin. Use: Treatment of group A streptococcal pharyngitis in patients with penicillin allergies.